Review
doi: 10.1038/nrm951.
Recombinational repair and restart of damaged replication forks
Affiliations
- PMID: 12415303
- DOI: 10.1038/nrm951
Item in Clipboard
Review
Recombinational repair and restart of damaged replication forks
Nat Rev Mol Cell Biol.
2002 Nov.
Abstract
Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.
Similar articles
-
Running into problems: how cells cope with replicating damaged DNA.Mutat Res. 2003 Nov 27;532(1-2):75-84. doi: 10.1016/j.mrfmmm.2003.08.011. Mutat Res. 2003. PMID: 14643430 Review.
-
Rescuing stalled or damaged replication forks.Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a012815. doi: 10.1101/cshperspect.a012815. Cold Spring Harb Perspect Biol. 2013. PMID: 23637285 Free PMC article. Review.
-
Mechanisms of dealing with DNA damage-induced replication problems.Cell Biochem Biophys. 2009;53(1):17-31. doi: 10.1007/s12013-008-9039-y. Epub 2008 Nov 26. Cell Biochem Biophys. 2009. PMID: 19034694 Review.
-
Links between DNA replication and recombination in prokaryotes.Curr Opin Genet Dev. 2004 Apr;14(2):107-12. doi: 10.1016/j.gde.2004.01.001. Curr Opin Genet Dev. 2004. PMID: 15196455 Review.
-
Interplay between DNA replication, recombination and repair based on the structure of RecG helicase.Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):49-59. doi: 10.1098/rstb.2003.1364. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15065656 Free PMC article. Review.
Cited by
-
Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast.EMBO J. 2005 Jun 1;24(11):2011-23. doi: 10.1038/sj.emboj.7600670. Epub 2005 May 5. EMBO J. 2005. PMID: 15889146 Free PMC article.
-
Topological locking restrains replication fork reversal.Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1500-5. doi: 10.1073/pnas.0609204104. Epub 2007 Jan 22. Proc Natl Acad Sci U S A. 2007. PMID: 17242356 Free PMC article.
-
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.EMBO J. 2007 Oct 3;26(19):4239-51. doi: 10.1038/sj.emboj.7601848. Epub 2007 Sep 13. EMBO J. 2007. PMID: 17853894 Free PMC article.
-
Assays used to study the DNA replication checkpoint in fission yeast.Methods Mol Biol. 2009;521:493-507. doi: 10.1007/978-1-60327-815-7_28. Methods Mol Biol. 2009. PMID: 19563125 Free PMC article.
-
The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.Mol Cell. 2008 Oct 10;32(1):118-28. doi: 10.1016/j.molcel.2008.08.024. Mol Cell. 2008. PMID: 18851838 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
