Serum bupropion levels in 2 breastfeeding mother-infant pairs

J Clin Psychiatry. 2002 Oct;63(10):910-1. doi: 10.4088/jcp.v63n1008.


Background: These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding.

Method: Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion.

Results: Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy.

Conclusion: We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / blood*
  • Antidepressive Agents, Second-Generation / metabolism
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Bipolar Disorder / blood
  • Bipolar Disorder / drug therapy
  • Breast Feeding*
  • Bupropion / blood*
  • Bupropion / metabolism
  • Bupropion / therapeutic use
  • Depression, Postpartum / blood*
  • Depression, Postpartum / drug therapy
  • Female
  • Humans
  • Infant*
  • Male
  • Maternal-Fetal Exchange*
  • Pregnancy
  • Risk Assessment


  • Antidepressive Agents, Second-Generation
  • Bupropion