Heparan sulfate fine structure and specificity of proteoglycan functions

Biochim Biophys Acta. 2002 Dec 19;1573(3):312-8. doi: 10.1016/s0304-4165(02)00398-7.

Abstract

Heparan sulfate chains have markedly heterogeneous structures in which distinct patterns of sulfation determine the binding specificity for ligand proteins. These "fine structures" of heparan sulfate are mainly produced by the regulated introduction of sulfate groups at the N-, 2-O-, 6-O-, and 3-O-positions of the sugar chain. Recent biochemical, histochemical, and genetic studies have demonstrated that different fine structures mediate distinct molecular recognition events to regulate a variety of cellular functions. In this review, we focus on the molecular basis of growth factor control by the sulfation status of heparan sulfate.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / metabolism
  • Fibroblast Growth Factors / metabolism
  • Heparan Sulfate Proteoglycans / metabolism*
  • Heparitin Sulfate / metabolism*
  • Ligands
  • Signal Transduction / physiology*
  • Sulfatases / metabolism

Substances

  • Heparan Sulfate Proteoglycans
  • Ligands
  • Fibroblast Growth Factors
  • Heparitin Sulfate
  • Sulfatases