Glycobiology of the synapse: the role of glycans in the formation, maturation, and modulation of synapses

Biochim Biophys Acta. 2002 Dec 19;1573(3):369-76. doi: 10.1016/s0304-4165(02)00405-1.

Abstract

Synapses, which are the fundamental functional unit of the nervous system, are considered to be highly specialized cell adhesion structures. Studies since the 1960s demonstrated that various carbohydrates and glycoproteins are expressed in synapses in the central and peripheral nervous system. Although the functional roles of these synaptic carbohydrates and glycoproteins remain to be determined, rapidly accumulating data suggest that they may play critical roles in the formation, maturation, and functional modulation of synapses.

Publication types

  • Review

MeSH terms

  • Agrin / metabolism
  • Animals
  • Central Nervous System / metabolism
  • Central Nervous System / physiology
  • Glycosylation
  • Heparan Sulfate Proteoglycans / metabolism
  • Heparitin Sulfate / metabolism
  • Membrane Glycoproteins / metabolism
  • Neuromuscular Junction / metabolism
  • Neuromuscular Junction / physiology*
  • Polysaccharides / metabolism*
  • Polysaccharides / physiology
  • Proteoglycans / metabolism
  • Sialic Acids / metabolism
  • Synapses / physiology*
  • Syndecan-2

Substances

  • Agrin
  • Heparan Sulfate Proteoglycans
  • Membrane Glycoproteins
  • Polysaccharides
  • Proteoglycans
  • Sialic Acids
  • polysialic acid
  • Syndecan-2
  • Heparitin Sulfate