YABBY polarity genes mediate the repression of KNOX homeobox genes in Arabidopsis

Plant Cell. 2002 Nov;14(11):2761-70. doi: 10.1105/tpc.004911.


The YABBY (YAB) genes specify abaxial cell fate in lateral organs in Arabidopsis. Loss-of-function mutants in two early-expressing YAB genes, FILAMENTOUS FLOWER (FIL) and YAB3, do not exhibit vegetative phenotypes as a result of redundancy. Mutations in these genes result in the derepression of the KNOX homeobox genes SHOOTMERISTEMLESS (STM), BREVIPEDICELLUS, and KNAT2 in the leaves and in the partial rescue of stm mutants. Here, we show that fil yab3 double mutants exhibit ectopic meristem formation on the adaxial surfaces of cotyledons and leaf blades. We propose that in addition to abaxial specification, lateral organ development requires YAB function to downregulate KNOTTED homeobox genes so that meristem initiation and growth are restricted to the apex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / genetics*
  • Genes, Homeobox / genetics
  • Homeodomain Proteins / genetics*
  • Meristem / growth & development
  • Mutation
  • Phenotype
  • Plant Proteins / genetics*
  • Suppression, Genetic / genetics


  • Arabidopsis Proteins
  • Homeodomain Proteins
  • Knox1 protein, plant
  • Plant Proteins
  • YABBY2 protein, Arabidopsis
  • YABBY3 protein, Arabidopsis