T1-insensitive flow suppression using quadruple inversion-recovery

Magn Reson Med. 2002 Nov;48(5):899-905. doi: 10.1002/mrm.10292.


A new flow suppression method has been proposed for the acquisition of blood-suppressed (black-blood) images in combination with administration of a positive contrast agent. The technique employs the quadruple inversion-recovery (QIR) preparative pulse sequence, which consists of two double-inversion modules followed by two delays. Within each double inversion, a nonselective RF pulse is immediately followed by a slice-selective one. The time intervals of the sequence can be calculated using an algorithm based on minimization of the variation of a signal equation over an entire range of T(1) occurring in blood before and after contrast administration. QIR is highly insensitive to variations of T(1), providing efficient suppression of a flow signal with T(1) in a range of 200-1200 ms. The technique utilizes identical scan parameters for pre- and postcontrast acquisition, and thus allows reliable quantitative interpretation of contrast enhancement (CE). The clinical application of QIR was demonstrated in high-resolution, contrast-enhanced, black-blood imaging of atherosclerotic plzzaque.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Contrast Media*
  • Humans
  • Image Enhancement / methods*
  • Magnesium Chloride
  • Magnetic Resonance Imaging / methods*
  • Models, Theoretical
  • Phantoms, Imaging


  • Contrast Media
  • Magnesium Chloride