Immunoglobulin genes: generating diversity with AID and UNG

Curr Biol. 2002 Oct 29;12(21):R725-7. doi: 10.1016/s0960-9822(02)01247-2.

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cytidine Deaminase / metabolism*
  • DNA Glycosylases*
  • Genes, Immunoglobulin*
  • Mice
  • N-Glycosyl Hydrolases / metabolism*
  • Uracil-DNA Glycosidase

Substances

  • DNA Glycosylases
  • N-Glycosyl Hydrolases
  • Uracil-DNA Glycosidase
  • AICDA (activation-induced cytidine deaminase)
  • Cytidine Deaminase