Telomeres: the molecular events driving end-to-end fusions

Curr Biol. 2002 Oct 29;12(21):R738-40. doi: 10.1016/s0960-9822(02)01252-6.


Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.

Publication types

  • Review
  • Comment

MeSH terms

  • DNA Ligase ATP
  • DNA Ligases / metabolism*
  • Telomere*


  • DNA Ligases
  • DNA Ligase ATP