Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats

Bull Exp Biol Med. 2002 May;133(5):494-6. doi: 10.1023/a:1019878224754.


Vilon (Lys-Glu) and Epithalon (Ala-Glu-Asp-Gly) administered orally for 1 month improved transport characteristics of the small intestine in aged rats. Vilon enhanced passive glucose accumulation in the serous fluid in inverted sac made from the distal region of the small intestine, while Epithalon enhanced this process in the medial region. Vilon stimulated active glucose accumulation in the serous sac of the medial small intestine, Epithalon - in the proximal and distal small intestinal segments. Glycine absorption increased only in the proximal intestinal segment under the effect of Epithalon.

MeSH terms

  • Absorption
  • Animals
  • Biological Transport
  • Body Weight / drug effects
  • Dipeptides / pharmacology*
  • Glucose / metabolism*
  • Glycine / metabolism*
  • Intestine, Small / metabolism*
  • Male
  • Oligopeptides / pharmacology*
  • Peptides / chemistry
  • Rats
  • Time Factors


  • Dipeptides
  • Oligopeptides
  • Peptides
  • lysylglutamic acid
  • Glucose
  • alanyl-glutamyl-aspartyl-glycine
  • Glycine