[Paget's disease of bone: study of 314 patients]

Med Clin (Barc). 2002 Oct 26;119(14):537-40. doi: 10.1016/s0025-7753(02)73487-8.
[Article in Spanish]


Background: To describe the clinical and laboratory features of Paget's disease of bone at the time of diagnosis.

Patients and method: This multicenter and retrospective study included 314 patients. Diagnosis was performed by means of characteristic radiological findings and typical bone scintigraphy. The variables analyzed included: epidemiological variables, cause of diagnosis, bone involvement, disease extension (Coutris index), complications, alkaline phosphate (AP) levels and disease activity (Renier index).

Results: There were 159 (50.5%) males and the mean age was 64.9 years (SD 12.6). Diagnosis was casual in 228 (72.6%) patients. Polyostotic involvement was detected in 201 (63.9%) patients. More common locations were pelvis, skull and lumbar spine. Sacrum was more frequently involved in men than in women (p < 0.05), whereas skull involvement was more common in women (p < 0.05). The number of bones involved was 3.1 SD 3 and the percentage of skeletal involvement was 8.7 % (SD 6.5). One hundred ninety eigth (63%) patients had complications. The disease was active in 242 (77%) patients with a mean AP value of 377 IU/L (SD 493); the activity of the disease measured by the Renier index was 34 (SD 46); the activity was greater in the skull and the humerus.

Conclusions: Paget's disease of bone is usually asymptomatic. Polyostotic involvement and activity are common at the time of diagnosis. Knowledge of the extension and activity by means of a mathematical model may aid to make therapeutical decisions.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alkaline Phosphatase / blood
  • Female
  • Fibrous Dysplasia, Polyostotic / diagnostic imaging
  • Fibrous Dysplasia, Polyostotic / epidemiology
  • Humans
  • Humerus / diagnostic imaging
  • Male
  • Middle Aged
  • Osteitis Deformans / blood
  • Osteitis Deformans / diagnostic imaging*
  • Osteitis Deformans / epidemiology
  • Radionuclide Imaging
  • Retrospective Studies
  • Severity of Illness Index
  • Skull / diagnostic imaging


  • Alkaline Phosphatase