Vacuolation in T-tubules as a model for tubular-vesicular transformations in biomembrane systems

Cell Biol Int. 2002;26(10):893-904. doi: 10.1006/cbir.2002.0945.


This review outlines the basic properties of T-tubules in skeletal muscle cells, and the factors that govern reversible vacuolation in T-tubules under experimental conditions. Comparable membranous transformations, involving the plasma membrane or occurring intracellularly, in non-muscle cells are then considered. Finally, the mechanisms of similar transformations in various model membrane systems are discussed. In view of the similarities between reversible vacuolation in the T-system and membrane transformations occurring in a variety of non-muscle cells, it is suggested that reversible vacuolation in T-tubules may be regarded as a general model for tubular-vesicular transformations in biomembranes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Cytoplasmic Vesicles / metabolism
  • Cytoplasmic Vesicles / ultrastructure
  • Humans
  • Intracellular Membranes / metabolism*
  • Intracellular Membranes / ultrastructure
  • Models, Biological
  • Muscle Cells / metabolism*
  • Muscle Cells / ultrastructure
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / ultrastructure
  • Organelles / metabolism
  • Organelles / ultrastructure
  • Vacuoles / metabolism*
  • Vacuoles / ultrastructure