Abstract
Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together with probenecid (Benemid). One patient had a concurrent transient increase in serum creatinine; both patients had a history of penicillin allergy and had previously received cephalexin intravenously. All abnormalities promptly remitted following discontinuation of therapy.
Publication types
-
Case Reports
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Administration, Oral
-
Adult
-
Cephalexin / administration & dosage
-
Cephalexin / adverse effects*
-
Cephalexin / therapeutic use
-
Drug Hypersensitivity
-
Endocarditis / drug therapy
-
Eosinophilia / chemically induced*
-
Eosinophilia / immunology
-
Hematuria / chemically induced*
-
Hematuria / immunology
-
Humans
-
Kidney Diseases / chemically induced*
-
Male
-
Probenecid / administration & dosage
-
Probenecid / therapeutic use