SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis

Bioinformatics. 2002 Nov;18(11):1540-1. doi: 10.1093/bioinformatics/18.11.1540.


SNOMAD is a collection of algorithms for the normalization and standardization of gene expression datasets derived from diverse biological and technological sources. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: (1). Local mean normalization; and (2). Local variance correction (Z-score generation using a locally calculated standard deviation).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Computer Communication Networks
  • Database Management Systems*
  • Databases, Nucleic Acid*
  • Gene Expression Profiling / methods*
  • Gene Expression Profiling / standards
  • Gene Expression Regulation
  • Information Storage and Retrieval / methods
  • Internet*
  • Models, Genetic
  • Models, Statistical
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Array Sequence Analysis / standards
  • Sequence Analysis, DNA / methods*
  • Sequence Analysis, DNA / standards
  • Software