GeneCards 2002: towards a complete, object-oriented, human gene compendium

Bioinformatics. 2002 Nov;18(11):1542-3. doi: 10.1093/bioinformatics/18.11.1542.


Motivation: In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving, state-of-the-art tools.

Results: GeneCards (Rebhan et al., 1998) has made innovative strides: (a). regular updates and enhancements incorporating new genes enriched with sequences, genomic locations, cDNA assemblies, orthologies, medical information, 3D protein structures, gene expression, and focused SNP summaries; (b). restructured software using object-oriented Perl, migration to schema-driven XML, and (c). pilot studies, introducing methods to produce cards for novel and predicted genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Chromosome Mapping / methods
  • Computer Communication Networks
  • Database Management Systems*
  • Databases, Genetic*
  • Gene Expression Profiling / methods
  • Genome, Human*
  • Humans
  • Information Storage and Retrieval / methods*
  • Internet*
  • Sequence Alignment / methods
  • Sequence Analysis / methods