Poxvirus Orthologous Clusters (POCs)

Bioinformatics. 2002 Nov;18(11):1544-5. doi: 10.1093/bioinformatics/18.11.1544.


Poxvirus Orthologous Clusters (POCs) is a JAVA client-server application which accesses an updated database containing all complete poxvirus genomes; it automatically groups orthologous genes into families based on BLASTP scores for assessment by a human database curator. POCs has a user-friendly interface permitting complex SQL queries to retrieve interesting groups of DNA and protein sequences as well as gene families for subsequent interrogation by a variety of integrated tools: BLASTP, BLASTX, TBLASTN, Jalview (multiple alignment), Dotlet (Dotplot), Laj (local alignment), and NAP (nucleotide to amino acid alignment).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cluster Analysis
  • DNA, Viral / classification
  • DNA, Viral / genetics
  • Database Management Systems*
  • Databases, Genetic
  • Documentation / methods
  • Genome, Viral*
  • Internet
  • Multimedia
  • Poxviridae / classification*
  • Poxviridae / genetics*
  • Sequence Alignment / methods
  • Sequence Analysis, DNA / methods
  • Software
  • User-Computer Interface


  • DNA, Viral