Immunology and immunomodulation of corneal transplantation

Int Rev Immunol. 2002 Mar-Jun;21(2-3):173-96. doi: 10.1080/08830180212064.


Corneal allografts are the oldest, most common, and most successful transplants performed on humans and animals. The cornea is endowed with a constellation of unique factors that contribute to its immune privilege and the low incidence of immune rejection. In spite of this immune privilege, 10 percent of first-time corneal grafts will undergo immune rejection. Several novel therapeutic strategies hold promise for modulating the alloimmune response by either promoting antigen-specific tolerance or redirecting the host's response from a Th1 pathway toward a Th2 pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anterior Chamber / immunology
  • Complement System Proteins / physiology
  • Corneal Transplantation / immunology*
  • Fas Ligand Protein
  • Graft Rejection / prevention & control
  • Graft Survival
  • Humans
  • Immune Tolerance
  • Isoantibodies / physiology
  • Langerhans Cells / immunology
  • Membrane Glycoproteins / physiology
  • T-Lymphocytes / immunology
  • Transplantation, Homologous


  • FASLG protein, human
  • Fas Ligand Protein
  • Isoantibodies
  • Membrane Glycoproteins
  • Complement System Proteins