Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates

Methods Enzymol. 2002;357:161-70. doi: 10.1016/s0076-6879(02)57675-8.
No abstract available

MeSH terms

  • Alkaline Phosphatase / genetics
  • Alkaline Phosphatase / metabolism
  • Animals
  • Binding Sites
  • Chloramphenicol O-Acetyltransferase / genetics
  • Chloramphenicol O-Acetyltransferase / metabolism
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Design
  • Drug Evaluation*
  • Enzyme Inhibitors / metabolism
  • Enzymes, Immobilized
  • Gene Expression Regulation / drug effects*
  • Genes, Reporter
  • Humans
  • Plasmids / genetics
  • Plasmids / metabolism
  • Pregnane X Receptor
  • Protein Binding
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Steroid / genetics
  • Receptors, Steroid / metabolism*

Substances

  • Enzyme Inhibitors
  • Enzymes, Immobilized
  • Pregnane X Receptor
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Cytochrome P-450 Enzyme System
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Chloramphenicol O-Acetyltransferase
  • Alkaline Phosphatase