Recent advances in hardware technology, noninvasiveness, lack of radiation and high diagnostic accuracy combine to allow the usage of magnetic resonance imaging (MRI) for disease screening in asymptomatic people. 175 volunteers were examined by means of a comprehensive 60-minute MR-screening-protocol covering four organ systems: the brain, the arterial vasculature, the heart and the colon. In 28% of the cases vascular pathology (cerebral, peripheral or cardiovascular) was detected. In up to 17% of the single examination parts relevant incidental findings were seen. The outlined comprehensive MR-protocol is an accurate and patient-friendly imaging tool for the detection of vascular pathology as well as colonic polyps. The socio-economic relevance of this screening exam has to be further investigated in larger patient cohorts.