Methotrexate-induced optic neuropathy

Clin Exp Ophthalmol. 2002 Dec;30(6):440-1. doi: 10.1046/j.1442-9071.2002.00578.x.


A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

Publication types

  • Case Reports

MeSH terms

  • Antirheumatic Agents / adverse effects*
  • Female
  • Humans
  • Methotrexate / adverse effects*
  • Middle Aged
  • Optic Atrophy / chemically induced*
  • Optic Nerve / drug effects*
  • Scotoma / chemically induced
  • Visual Acuity / drug effects


  • Antirheumatic Agents
  • Methotrexate