Glycemic index in chronic disease: a review

Eur J Clin Nutr. 2002 Nov;56(11):1049-71. doi: 10.1038/sj.ejcn.1601454.

Abstract

Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states.

Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety.

Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

Publication types

  • Review

MeSH terms

  • Area Under Curve
  • Blood Glucose / metabolism*
  • Chronic Disease
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / prevention & control
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / classification
  • Dietary Carbohydrates / metabolism
  • Exercise / physiology
  • Food / classification*
  • Glycemic Index*
  • Heart Diseases / etiology*
  • Heart Diseases / prevention & control
  • Humans
  • Hyperinsulinism / etiology
  • Hyperinsulinism / prevention & control
  • Insulin / metabolism
  • Insulin Resistance
  • Neoplasms / etiology*
  • Neoplasms / prevention & control
  • Obesity / metabolism
  • Postprandial Period

Substances

  • Blood Glucose
  • Dietary Carbohydrates
  • Insulin