Postsurgery Enteral Nutrition in Head and Neck Cancer Patients

Eur J Clin Nutr. 2002 Nov;56(11):1126-9. doi: 10.1038/sj.ejcn.1601458.

Abstract

Objective: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using an arginine-enriched diet, could improve nutritional variables as well as clinical outcomes.

Design: Randomized clinical trial.

Setting: Tertiary care.

Subjects: A population of 47 patients with oral and laryngeal cancer were enrolled.

Interventions: At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplemented with arginine and fiber (group I); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II).

Results: No significant intergroup differences in the trend of the three plasma proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (17.4% group I and 8.3% group II; NS). During the 3 months after hospital discharge five patients died; no differences were detected between groups (13% group I and 8.3% group II; NS). The incidences postoperative infection complications were similar (nine patients) in both groups (21.7% group I and 16.7% group II; NS). Fistula were less frequent in enriched nutrition group (0% group I and 20.8% group II; P<0.05); wound infection was more frequent in group II, but without statistical difference (4.3% group I and 12.5% group II; NS). The length of postoperative stay was 22.8+/-11.8 days in the enriched group and 31.2+/-19.1 days in the control group (P=0.07).

Conclusions: In conclusion, enriched formula improves local wound complications in postoperative head and neck cancer patients. Our results suggest that these patients could benefit from an immunonutrient-enhanced enteral formula.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Arginine / administration & dosage*
  • Arginine / therapeutic use
  • Dietary Fiber / administration & dosage*
  • Dietary Fiber / therapeutic use
  • Enteral Nutrition*
  • Female
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / immunology
  • Head and Neck Neoplasms / surgery*
  • Head and Neck Neoplasms / therapy*
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Mortality
  • Nutrition Disorders / immunology
  • Nutrition Disorders / prevention & control
  • Nutritional Status
  • Postoperative Care
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Surgical Wound Infection / epidemiology
  • Treatment Outcome

Substances

  • Dietary Fiber
  • Arginine