The restriction point of the cell cycle

Cell Cycle. Mar-Apr 2002;1(2):103-10.


As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell biological experiments, yet allowing accurate molecular predictions and spurring a search for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as outlined here is more interesting and far more complex. We discuss the relationship between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Division
  • Cyclin D
  • Cyclin D1 / metabolism
  • Cyclin E / metabolism
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclins / metabolism
  • Feedback, Physiological
  • G1 Phase
  • Humans
  • MAP Kinase Signaling System
  • Mitogens
  • Proto-Oncogene Proteins c-myc / metabolism
  • Signal Transduction*


  • Cyclin D
  • Cyclin E
  • Cyclins
  • Mitogens
  • Proto-Oncogene Proteins c-myc
  • Cyclin D1
  • Cyclin-Dependent Kinases