Abstract
Cell cycle checkpoints constitute a network of signal transduction mechanisms to monitor DNA damage and replication and thereby regulate progression through the cell cycle. A series of events is triggered in cells upon DNA damage. Here we describe a framework for the understanding of the functions of the core components involved in the cell cycle response to DNA damage and the relevance to the origin of cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Cycle*
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Checkpoint Kinase 2
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Cyclin-Dependent Kinase Inhibitor p21
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Cyclins / metabolism
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DNA Damage*
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G2 Phase*
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Humans
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Mitosis*
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Models, Biological
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Neoplasms / metabolism*
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases*
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Signal Transduction*
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Tumor Suppressor Protein p53 / metabolism*
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Ultraviolet Rays
Substances
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CDKN1A protein, human
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Cyclin-Dependent Kinase Inhibitor p21
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Cyclins
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Tumor Suppressor Protein p53
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Protein Kinases
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Checkpoint Kinase 2
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CHEK2 protein, human
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Protein Serine-Threonine Kinases