No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese

Cancer Lett. 2002 Jul 8;181(1):81-5. doi: 10.1016/s0304-3835(02)00041-1.

Abstract

A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or cases as a whole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • DNA-Binding Proteins / genetics*
  • Digestive System Neoplasms / genetics*
  • Esophageal Neoplasms / genetics
  • Exons
  • Female
  • Gastrointestinal Neoplasms / genetics
  • Gene Frequency
  • Genes, Tumor Suppressor
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Nuclear Proteins / genetics*
  • Polymorphism, Genetic*
  • Tumor Protein p73
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Proteins

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • TP73 protein, human
  • Tumor Protein p73
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins