Interleukin-15 and the regulation of lymphoid homeostasis

Mol Immunol. 2002 Dec;39(9):537-44. doi: 10.1016/s0161-5890(02)00211-0.


Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Homeostasis
  • Immunologic Memory
  • Interleukin-15 / physiology*
  • Interleukin-2 / physiology
  • Lymphocyte Activation
  • Lymphocytes / immunology*
  • Receptors, Interleukin-15
  • Receptors, Interleukin-2 / metabolism
  • Signal Transduction
  • T-Lymphocytes / immunology


  • Interleukin-15
  • Interleukin-2
  • Receptors, Interleukin-15
  • Receptors, Interleukin-2