Role of Akt/protein kinase B in metabolism

Trends Endocrinol Metab. 2002 Dec;13(10):444-51. doi: 10.1016/s1043-2760(02)00662-8.

Abstract

Since its discovery more than a decade ago, the Ser/Thr kinase Akt/PKB (protein kinase B) has been recognized as being remarkably well conserved across a broad range of species and involved in a diverse array of cellular processes. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues. Refining our understanding of those pivotal molecular components that normally coordinate insulin action throughout the body is essential for a full understanding of insulin resistance in diabetes mellitus and ultimately the successful treatment of this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Base Sequence
  • Diabetes Mellitus, Type 2 / physiopathology
  • Disease Models, Animal
  • Energy Metabolism / physiology*
  • Glucose / metabolism*
  • Glucose Transporter Type 4
  • Glycogen / biosynthesis
  • Insulin / metabolism*
  • Lipid Metabolism
  • Liver / metabolism
  • Mice
  • Molecular Sequence Data
  • Monosaccharide Transport Proteins / metabolism
  • Muscle Proteins*
  • Muscles / metabolism
  • Nitric Oxide Synthase / metabolism
  • Pancreas / metabolism
  • Protein Biosynthesis
  • Protein Isoforms
  • Protein-Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-akt

Substances

  • Glucose Transporter Type 4
  • Insulin
  • Monosaccharide Transport Proteins
  • Muscle Proteins
  • Protein Isoforms
  • Proto-Oncogene Proteins
  • Slc2a4 protein, mouse
  • Glycogen
  • Nitric Oxide Synthase
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Glucose