Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor

Neuropsychopharmacology. 2002 Nov;27(5):869-73. doi: 10.1016/S0893-133X(02)00353-6.


Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electroencephalography / methods
  • Electroencephalography / statistics & numerical data
  • Homeostasis / genetics*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mutation / physiology
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin / deficiency*
  • Receptors, Serotonin / genetics
  • Sleep / genetics*
  • Sleep Deprivation / genetics
  • Sleep Deprivation / metabolism


  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin