The Collaborative HIV Prevention Research in Minority Communities Program was developed to address the simultaneous overrepresentation of communities of color among those with HIV and under-representation of researchers of color at the National Institutes of Health. The program is designed to help scientists develop their programs of research and obtain significant research funding. The 27-month program has the following elements: small grant funding, a structured summer program, individualized long-term research collaboration, access to behavioral science expertise, and internal peer review of all products. To date, the 19 program participants, eight of whom have not completed the program, have received almost $11,000,000 in research funding and have conducted culturally specific research with communities of color. In addition, a network of HIV prevention investigators of color has been created. Institutes throughout the National Institutes of Health (NIH) and other entities could use this model to develop investigators of color, improve the quality of research with communities of color, and begin to address health disparities.