Prostaglandin E synthase

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:383-99. doi: 10.1016/s0090-6980(02)00043-6.

Abstract

Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Amino Acid Sequence
  • Animals
  • Arachidonic Acid / metabolism
  • Bone and Bones / metabolism
  • Cyclooxygenase 2
  • Fever / metabolism
  • Glutathione Transferase / metabolism
  • Humans
  • Inflammation / metabolism
  • Intramolecular Oxidoreductases / chemistry
  • Intramolecular Oxidoreductases / genetics
  • Intramolecular Oxidoreductases / metabolism*
  • Isoenzymes / genetics
  • Isoenzymes / metabolism*
  • Membrane Proteins
  • Molecular Sequence Data
  • Neoplasms / metabolism
  • Pain / metabolism
  • Prostaglandin-E Synthases
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Reproduction / physiology
  • Sequence Alignment

Substances

  • Isoenzymes
  • Membrane Proteins
  • Arachidonic Acid
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases
  • Glutathione Transferase
  • Intramolecular Oxidoreductases
  • Prostaglandin-E Synthases