Human demographic history: refining the recent African origin model

Curr Opin Genet Dev. 2002 Dec;12(6):675-82. doi: 10.1016/s0959-437x(02)00350-7.


Recent studies of large portions of the human genome support a recent origin of modern humans from an African stock after a bottleneck of moderate size followed by a range expansion out of Africa. Under this simple scenario, patterns of molecular diversity suggest that balancing selection could be more prevalent than positive selection in coding regions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Africa
  • Evolution, Molecular*
  • Genetic Variation
  • Genetics, Population
  • Genome, Human*
  • Humans
  • Linkage Disequilibrium
  • Population Dynamics
  • Selection, Genetic