Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy

Circ Res. 2002 Nov 15;91(10):888-98. doi: 10.1161/01.res.0000041680.43270.f8.


Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Calcium / metabolism
  • Cardiomegaly / pathology
  • Cardiomegaly / physiopathology*
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix / pathology
  • Humans
  • MAP Kinase Signaling System
  • Myocardium / metabolism
  • Myocardium / pathology
  • Receptors, Cell Surface / metabolism
  • Signal Transduction* / physiology


  • Receptors, Cell Surface
  • Calcium