Genetically engineered T-cells for adoptive immunotherapy

Curr Opin Mol Ther. 2002 Oct;4(5):467-75.


Adaptive immunotherapy with T-cells is being evaluated as therapy for a number of malignancies and viral infections. Genetic modification of infused T-cells has been used for several years to track such cells, to redirect and augment the immune response towards tumors, and to provide a means of ablating infused T-cells should adverse effects occur. New strategies to target T-cells to tumors and to genetically modify them to make them resistant to tumor evasion mechanisms are being evaluated in preclinical models.

Publication types

  • Review

MeSH terms

  • Genetic Engineering*
  • Humans
  • Immunotherapy, Adoptive*
  • T-Lymphocytes / immunology*