Abstract
Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aconitine / analogs & derivatives*
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Aconitine / pharmacology*
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Adrenal Glands / drug effects*
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Animals
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Cattle
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Cells, Cultured
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Inhibitory Concentration 50
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Models, Chemical
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Nicotinic Antagonists / pharmacology*
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Receptors, Nicotinic / metabolism*
Substances
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Nicotinic Antagonists
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Receptors, Nicotinic
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nicotinic receptor alpha3beta4
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methyllycaconitine
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Aconitine