Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors

Ann N Y Acad Sci. 2002 Oct:971:139-41. doi: 10.1111/j.1749-6632.2002.tb04448.x.


Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aconitine / analogs & derivatives*
  • Aconitine / pharmacology*
  • Adrenal Glands / drug effects*
  • Animals
  • Cattle
  • Cells, Cultured
  • Inhibitory Concentration 50
  • Models, Chemical
  • Nicotinic Antagonists / pharmacology*
  • Receptors, Nicotinic / metabolism*


  • Nicotinic Antagonists
  • Receptors, Nicotinic
  • nicotinic receptor alpha3beta4
  • methyllycaconitine
  • Aconitine