Orchestrating the unfolded protein response in health and disease

J Clin Invest. 2002 Nov;110(10):1389-98. doi: 10.1172/JCI16886.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Activating Transcription Factor 6
  • Apoptosis
  • DNA-Binding Proteins / metabolism
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / metabolism
  • Endoplasmic Reticulum / metabolism
  • Endoribonucleases
  • Enzyme Activation
  • Genetic Diseases, Inborn / genetics
  • Genetic Diseases, Inborn / metabolism
  • Glucose / metabolism
  • Humans
  • Hyperhomocysteinemia / genetics
  • Hyperhomocysteinemia / metabolism
  • Ischemia / metabolism
  • Membrane Proteins*
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Organelles / metabolism
  • Protein Folding*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • RNA Splicing
  • Signal Transduction
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism
  • Transcription Factors / metabolism
  • Virus Diseases / etiology
  • Virus Diseases / metabolism
  • eIF-2 Kinase / metabolism

Substances

  • ATF6 protein, human
  • Activating Transcription Factor 6
  • DNA-Binding Proteins
  • Membrane Proteins
  • Transcription Factors
  • ERN2 protein, human
  • PERK kinase
  • Protein-Serine-Threonine Kinases
  • eIF-2 Kinase
  • Endoribonucleases
  • Glucose