Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain

Cytogenet Genome Res. 2002;97(1-2):68-71. doi: 10.1159/000064058.


Leucine-rich acidic nuclear protein (LANP) is a member of the leucine-rich repeats (LRRs) superfamily. Here we report on a human homologue of LANP, encoded by the gene ANP32E (alias LANPL). The gene was cloned and identified during large-scale sequencing analysis of a human fetal brain cDNA library. The human protein shared 70% amino acid identity with rat LANP. According to bioinformatics analysis, ANP32E is located on chromosome 1q22. RT-PCR analysis indicates that ANP32E was expressed in human peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1 / genetics
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Female
  • Fetus / metabolism
  • Gene Expression
  • Gene Library
  • Humans
  • Male
  • Molecular Chaperones
  • Molecular Sequence Data
  • Neuropeptides / genetics*
  • Nuclear Proteins / genetics*
  • Phosphoproteins
  • Pregnancy
  • Rats
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Tissue Distribution


  • ANP32E protein, human
  • Anp32a protein, rat
  • DNA, Complementary
  • Molecular Chaperones
  • Neuropeptides
  • Nuclear Proteins
  • Phosphoproteins

Associated data

  • GENBANK/AY057381