Isolation and characterization of a human novel RAB (RAB39B) gene

Cytogenet Genome Res. 2002;97(1-2):72-5. doi: 10.1159/000064047.


Rab proteins are small-molecular-weight GTPases that control vesicular trafficking in eukaryotic cells. During the large-scale sequencing analysis of a human fetal brain cDNA library, we isolated a cDNA clone encoding a novel Rab protein, which showed 74.2% identity with previously isolated Rab39A at the amino acid level. RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28. It consisted of two exons spanning 3764 bp of human genomic DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, X / genetics
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • Exons
  • Female
  • Gene Library
  • Genes, ras
  • Humans
  • Male
  • Molecular Sequence Data
  • Pregnancy
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • rab GTP-Binding Proteins / genetics*


  • DNA, Complementary
  • RNA, Messenger
  • rab GTP-Binding Proteins