Conservation of avian Z chromosomes as revealed by comparative mapping of the Z-linked aldolase B gene

Cytogenet Genome Res. 2002;96(1-4):176-8. doi: 10.1159/000063019.


A chicken Z-linked BAC probe containing the aldolase B gene was used for fluorescence in-situ hybridization (FISH) mapping in four different avian species. The biotinylated BAC clone showed distinct unique hybridization sites on the structurally different Z chromosomes. This result, together with previous data, lends credence to the notion that, despite undergoing structural rearrangements, the gene content of the avian Z chromosome remained conserved during evolution. Our study also demonstrates the feasibility of using large genomic clones for comparative mapping of Z-linked genes in birds.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Birds
  • Cells, Cultured
  • Chick Embryo
  • Chromosome Mapping*
  • Coturnix / embryology
  • Coturnix / genetics*
  • Ducks
  • Embryo, Nonmammalian / physiology
  • Fibroblasts / cytology
  • Fructose-Bisphosphate Aldolase / genetics*
  • In Situ Hybridization, Fluorescence


  • Fructose-Bisphosphate Aldolase