Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

Biochem Soc Trans. 2002 Nov;30(Pt 6):1091-5. doi: 10.1042/bst0301091.


Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / chemistry
  • CCAAT-Enhancer-Binding Proteins / metabolism*
  • Cholesterol / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Lipid Metabolism*
  • Models, Biological
  • NADP / metabolism
  • Protein Isoforms
  • Sterol Regulatory Element Binding Protein 1
  • Structure-Activity Relationship
  • Transcription Factors*
  • Transcriptional Activation*


  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Protein Isoforms
  • SREBF1 protein, human
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • NADP
  • Cholesterol