The article examines ethical considerations related to the design and implementation of rehabilitation research. The authors' primary thesis is that ethical research practice requires rehabilitation and disability studies scholars to (a) adhere to the standards of conduct promulgated in the canons of ethics of such organizations as the American Psychological Association, the American Counseling Association, and the American Rehabilitation Counseling Association in all interactions with people with disabilities and (b) maintain vigilance in protecting the rights and safety of participants in specific investigations.