Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background

Eur J Immunol. 2002 Dec;32(12):3463-71. doi: 10.1002/1521-4141(200212)32:12<3463::AID-IMMU3463>3.0.CO;2-B.


The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology*
  • Cell Differentiation
  • Ficoll / analogs & derivatives*
  • Ficoll / immunology
  • Gene Expression Regulation, Developmental
  • Genes, Immunoglobulin*
  • Immunization
  • Immunoglobulin Isotypes / biosynthesis
  • Immunoglobulin Isotypes / genetics
  • Immunoglobulin M / biosynthesis
  • Immunoglobulin M / genetics
  • Immunoglobulin mu-Chains / genetics*
  • Immunoglobulins / biosynthesis*
  • Immunoglobulins / genetics*
  • Lipopolysaccharides / immunology
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • Lymphopoiesis / genetics
  • Lymphopoiesis / immunology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutation*
  • Trinitrobenzenes / immunology


  • Immunoglobulin Isotypes
  • Immunoglobulin M
  • Immunoglobulin mu-Chains
  • Immunoglobulins
  • Lipopolysaccharides
  • TNP-ficoll
  • Trinitrobenzenes
  • trinitrophenyl-lipopolysaccharide
  • Ficoll