Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children

Vaccine. 2002 Nov 22;21(1-2):138-45. doi: 10.1016/s0264-410x(02)00348-1.


Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Antibodies, Bacterial / biosynthesis*
  • Calibration
  • Child
  • Child, Preschool
  • Cholera Vaccines / administration & dosage
  • Cholera Vaccines / immunology*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Infant
  • Male
  • Nicaragua
  • Safety
  • Serologic Tests
  • Sweden
  • Vaccination*
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology*
  • Vibrio cholerae / immunology*


  • Antibodies, Bacterial
  • Cholera Vaccines
  • Vaccines, Inactivated