Abstract
The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. The new compound was found to be less active in vitro than adriamycin against L1210 and the sensitive cell lines KB-3-1 and MES-SA, but retained interesting cytotoxicity against the adriamycin resistant subline KB-A1 and the multidrug resistant MES-SA/Dx5 subline.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / chemical synthesis
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Antibiotics, Antineoplastic / pharmacology
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Carbohydrates / chemistry
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Cell Division / drug effects
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Daunorubicin / analogs & derivatives*
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Doxorubicin / pharmacology
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Drug Resistance, Multiple
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Humans
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Hydrophobic and Hydrophilic Interactions
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Inhibitory Concentration 50
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Mice
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Naphthacenes / chemical synthesis*
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Naphthacenes / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antibiotics, Antineoplastic
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Carbohydrates
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Naphthacenes
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Doxorubicin
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daunomycinone
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Daunorubicin