Abstract
A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line.
MeSH terms
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Animals
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Aristolochic Acids / chemical synthesis*
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Aristolochic Acids / pharmacology*
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Cell Survival / drug effects
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Inhibitory Concentration 50
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Lactams
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Leukemia L1210 / pathology
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Mice
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Aristolochic Acids
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Lactams