Immune downregulation leads to upregulation of an antiviral response: a lesson from the hepatitis B virus

Microbes Infect. 2002 Nov;4(13):1317-26. doi: 10.1016/s1286-4579(02)00012-6.

Abstract

Induction of tolerance towards antigens that drive susceptibility or pathology may be considered a new mode of treatment for several infections. Hepatitis B virus is a non-cytopathic virus, and oral immune regulation was shown to be effective in modulation of the immune-mediated liver injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / immunology
  • Administration, Oral
  • Antigens, Viral / administration & dosage
  • Antigens, Viral / immunology
  • Chronic Disease
  • Down-Regulation
  • Hepatitis B / immunology*
  • Hepatitis B / therapy
  • Hepatitis B virus / immunology*
  • Immune Tolerance*
  • Liver Diseases / immunology
  • Models, Immunological
  • Up-Regulation

Substances

  • Antigens, Viral