Endothelin receptor antagonists and cerebral vasospasm: an update

Neurosurgery. 2002 Dec;51(6):1333-41; discussion 1342.


THIS REVIEW UPDATES: the current status of endothelin receptor antagonists in the treatment of cerebral vasospasm. Recent preclinical and clinical studies are reviewed, as well as clinical trials for other medical indications. Some of the newer endothelin receptor antagonists are also examined.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelin Receptor Antagonists*
  • Endothelins / metabolism
  • Humans
  • Receptors, Endothelin / metabolism
  • Vasospasm, Intracranial / drug therapy*
  • Vasospasm, Intracranial / metabolism
  • Vasospasm, Intracranial / physiopathology


  • Endothelin Receptor Antagonists
  • Endothelins
  • Receptors, Endothelin