Growth signaling: TSC takes its place

Curr Biol. 2002 Nov 19;12(22):R785-7. doi: 10.1016/s0960-9822(02)01294-0.

Abstract

The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / genetics
  • Cell Size
  • Genes, Tumor Suppressor*
  • Growth / genetics*
  • Humans
  • Proteins / genetics*
  • Repressor Proteins / genetics
  • Signal Transduction
  • Tuberous Sclerosis Complex 1 Protein
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins

Substances

  • Proteins
  • Repressor Proteins
  • TSC1 protein, human
  • TSC2 protein, human
  • Tuberous Sclerosis Complex 1 Protein
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins