Cytoskeleton: what does GTP do for septins?

Curr Biol. 2002 Nov 19;12(22):R788-90. doi: 10.1016/s0960-9822(02)01295-2.


The recent observation of GTP-promoted polymerization of a single septin polypeptide suggests that this protein has tubulin-like biochemical properties. This model cannot, however, explain the GTP-biochemistry of heteromeric septin complexes from cytosol.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cytoskeleton / physiology*
  • GTP-Binding Proteins / metabolism*
  • Guanosine Triphosphate / metabolism*
  • Mammals
  • Protein Folding
  • Recombinant Proteins / metabolism


  • Recombinant Proteins
  • Guanosine Triphosphate
  • GTP-Binding Proteins