Prediction of Creatinine Clearance From Serum Creatinine

Nephron. 1976;16(1):31-41. doi: 10.1159/000180580.

Abstract

A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Body Weight
  • Creatinine / blood*
  • Creatinine / urine
  • Humans
  • Kidney / physiology*
  • Male
  • Mathematics
  • Methods
  • Middle Aged

Substances

  • Creatinine