Abstract
The intravenous application of 60 mg streptozotocin/kg body weight to a Hanford miniature pig 8 days after a first dose of 30 mg/kg led to a diabetes with loss of insulin response to glucose, hyperglycaemia, glucosuria and a considerable increase of triglycerides and cholesterol. The application of 40 mg streptozotocin/kg to a second pig had no effect.
MeSH terms
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Animals
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Blood Glucose / analysis
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Body Weight
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Cholesterol / blood
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Diabetes Mellitus / blood
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Diabetes Mellitus / chemically induced*
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Female
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Glycosuria / chemically induced
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Hyperglycemia / chemically induced
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Injections, Intravenous
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Insulin / blood
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Male
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Radioimmunoassay
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Species Specificity
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Streptozocin / administration & dosage
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Streptozocin / adverse effects*
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Swine*
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Triglycerides / blood
Substances
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Blood Glucose
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Insulin
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Triglycerides
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Streptozocin
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Cholesterol