[Streptozotocin diabetes in a miniature pig (author's transl)]

Res Exp Med (Berl). 1975;165(1):61-5. doi: 10.1007/BF01856450.
[Article in German]

Abstract

The intravenous application of 60 mg streptozotocin/kg body weight to a Hanford miniature pig 8 days after a first dose of 30 mg/kg led to a diabetes with loss of insulin response to glucose, hyperglycaemia, glucosuria and a considerable increase of triglycerides and cholesterol. The application of 40 mg streptozotocin/kg to a second pig had no effect.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Body Weight
  • Cholesterol / blood
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / chemically induced*
  • Female
  • Glycosuria / chemically induced
  • Hyperglycemia / chemically induced
  • Injections, Intravenous
  • Insulin / blood
  • Male
  • Radioimmunoassay
  • Species Specificity
  • Streptozocin / administration & dosage
  • Streptozocin / adverse effects*
  • Swine*
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Insulin
  • Triglycerides
  • Streptozocin
  • Cholesterol