Similarities between the Hedgehog and Wnt signaling pathways

Trends Cell Biol. 2002 Nov;12(11):523-31. doi: 10.1016/s0962-8924(02)02388-7.


Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling pathways. These kinases silence both pathways by labeling a key transcription factor (Cubitus interruptus) or co-activator (beta-catenin) for proteolysis, and it is possible that reversal of these phosphorylation events is, in each case, central to pathway activation. This review compares the two pathways to explore whether our more extensive knowledge of Wnt pathways can be of predictive value for investigating Hedgehog signaling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytoskeletal Proteins / physiology*
  • Drosophila
  • Drosophila Proteins / physiology*
  • Hedgehog Proteins
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction / physiology*
  • Trans-Activators / physiology*
  • Wnt Proteins
  • Zebrafish Proteins*
  • beta Catenin


  • Cytoskeletal Proteins
  • Drosophila Proteins
  • Hedgehog Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Wnt Proteins
  • Zebrafish Proteins
  • beta Catenin
  • hh protein, Drosophila